The study, conducted by M. Utley and colleagues of the University College London, concludes in a general sense that radical surgeries and multimodality treatments, where available, tend to improve patient survival by a substantial margin.
Malignant mesothelioma, or a cancerous tumor of the mesothelial tissue, is a terminal disease which is caused by exposure to toxic asbestos fibers. Asbestos fibers which are accidentally ingested or inhaled become lodged in the mesothelial tissues surrounding the lungs after slipping through the lung tissue itself. The fibers instigate a scarring-like reaction in the mesothelium which can develop into malignant tumors given enough time. Mesothelioma can take anywhere from ten to fifty years to develop after initial exposure, and often presents with vague, general symptoms.
The study headed by M. Utley compared the survival rates of several different sets of patients. Patients who underwent no surgery were compared with those who underwent three separate levels of increasingly radical treatment regimens. The three types of treatment covered in the study were as follows:
* Thoracotomy: An incision in the chest cut through which to remove a tumor
* Resection: Affected tissues and / or organs (mesothelium and sometimes lung) are completely removed
* Multimodality: Affected tissues are removed and the are is treated with a direct application of chemotherapy
The results showed that patients who did not undergo surgery survived a mean of 16.8 months, thoracotomy patients survived a mean of 17.8 months, resection patients survived a mean of 17 months and multimodality patients survived a surprising 32.9 months.
While the results appear to demonstrate that more radical surgeries produce better results, it’s important to know that younger, healthier patients tend to be better candidates for radical treatment, and that those patients are often expected to survive longer to begin with.
“Given the burden of morbidity of resection in the management of pleural mesothelioma,” concluded the researchers, “this most optimistic estimate of the magnitude of any survival benefit should be taken into account in any policy decision, in clinical trial proposals and in strategies adopted by clinical teams.”
SourceSeptember 15, 2010 in General Mesothelioma News | Permalink Comments Verify your Comment Previewing your CommentPosted by: |
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